The few available studies point, so far, to the CLRs, MGL-1, and DC-SIGN receptors as being relevant in tumor recognition and undesired tolerance induction (37, 146): the former is highly expressed in immature, tolerogenic DCs, and shown to interact with the tumor-associated Tn antigen-bearing forms of MUC1 (147); the latter is also expressed by immature DCs and recognizes Lex and Lewis Y (Ley) glycoantigens in a carcinoembryonic antigen-context expressed in colorectal carcinoma. The gene discussed is LLGL1; the disease is neoplasm.