Although the NLRP3 inflammasome is activated during many parasitic infections (e.g., Leishmania major) or by byproducts of parasitic infections (e.g., malarial hemozoin) and its effect on the acute innate immune response is well documented, the role of NLRP3 or other NLRs in the adaptive immune response to parasites has not been extensively studied (99, 100). Here, NLRP3 is linked to parasitic infectious disease.