NLRP1 and rheumatoid arthritis: Interestingly, non-synonymous coding-region and promoter polymorphisms in Nlrp1 have been recurrently identified in genetic screens for a number of autoimmune diseases including vitiligo (melanocytes in the skin and hair targeted), Addison’s disease (cortex of the adrenal gland targeted), type 1 diabetes (beta cells in the pancreas targeted), systemic sclerosis (nuclear antigens targeted), RA (synovium in joints targeted), and SLE (nuclear antigens targeted) (190, 191, 195, 203–206).