Interestingly, non-synonymous coding-region and promoter polymorphisms in Nlrp1 have been recurrently identified in genetic screens for a number of autoimmune diseases including vitiligo (melanocytes in the skin and hair targeted), Addison’s disease (cortex of the adrenal gland targeted), type 1 diabetes (beta cells in the pancreas targeted), systemic sclerosis (nuclear antigens targeted), RA (synovium in joints targeted), and SLE (nuclear antigens targeted) (190, 191, 195, 203–206). This evidence concerns the gene NLRP1 and type 1 diabetes mellitus.