Flagella from Salmonella, Yersinia, and Pseudomonas activate the NLRC4 inflammasome in splenic CD8α+ DCs to release IL-1β and IL-18; IL-18 can stimulate IFN-γ production from non-cognate memory CD8+ T cells in the spleen thereby enhancing host resistance to bacterial infection (83). Here, CD8A is linked to bacterial infectious disease.