IL1A and allergic disease: As many murine allergy models involve intraperitoneal administration of antigen with the potent adjuvant aluminum hydroxide, the role of NLRs during the T cell sensitization phase to allergens in lung draining lymph nodes is difficult to determine (139); indeed intraperitoneal injection models have demonstrated a range of effects in IL-1- or IL-1 receptor-deficient or inflammasome-deficient mice (113, 140, 141).