The primary nuclear antigen, double stranded DNA (dsDNA) can potentially act as a DAMP to trigger many PRRs including TLR7 and TLR9 (199), NLRP3 (200), and AIM2 (201) and each of these receptors has been implicated in the pathogenesis of lupus. Here, AIM2 is linked to systemic lupus erythematosus.