PANX1 and neoplasm: Extending on the earlier findings by Pelegrin and colleagues, in the J774 monocyte macrophage cell line derived from a BALB/C mouse tumor, Iglesias et al. (2008) showed that Panx1 activation was tightly coupled to P2X7 receptor activation via a Panx1/P2X7 receptor complex involving a Src family tyrosine kinase (SFK).