Panx1 forms large pore channels permeable to ions and small molecules, and is a clinically relevant protein in inflammatory conditions (Kanneganti et al., 2007; Silverman et al., 2009; Gulbransen et al., 2012; Diezmos et al., 2013), stroke (Thompson et al., 2006; Bargiotas et al., 2011; Bargiotas et al., 2012; Dvoriantchikova et al., 2012), and cancer (Lai et al., 2007; Cowan et al., 2012; Penuela et al., 2012). Here, PANX1 is linked to stroke disorder.