Interestingly, the alteration of Tau alternative splicing in DM1 also seems to be tissue specific, as mis-splicing of exon 2 is observed in both brain and skeletal muscle, whereas mis-splicing of exon 6 (decrease in exon 6c and increase in 6d) is only observed in the brain (Leroy et al., 2006a). Here, MAPT is linked to myotonic dystrophy type 1.