Although all tauopathies are characterized by intraneuronal Tau aggregates, their clinical symptoms and histopathological criteria differ, including the structure of the aggregates (paired helical filaments, straight filaments or Pick bodies), the cerebral localization of degenerating neurons, the presence or absence of glial Tau inclusions (astrocytic plaques, tuft-shaped astrocytes, and oligodendroglial coiled bodies), and the association with other types of neuropathological lesions, such as extracellular amyloid deposits or Lewy bodies (LBs) [reviewed in Sergeant et al. (2005)]. The gene discussed is MAPT; the disease is tauopathy.