Although Bin1 mis-splicing has not been established in the DM brain, Bin1 is a recently identified genetic marker for predisposition to the most frequent tauopathy, AD (Seshadri et al., 2010; Carrasquillo et al., 2011; Lambert et al., 2011; Logue et al., 2011; Wijsman et al., 2011). This evidence concerns the gene BIN1 and Alzheimer disease.