Furthermore, the propagation of Tau pathology has recently been reported in animals after the injection of insoluble material obtained from animal models of AD, the brains of AD patients, or a lentivirus encoding wild type Tau (Clavaguera et al., 2009, 2013; De Calignon et al., 2012; Lasagna-Reeves et al., 2012; Caillierez et al., 2013). Here, MAPT is linked to Alzheimer disease.