This relationship between Tau inclusion and pathophysiology is supported by the identification of autosomal dominant mutations in the MAPT gene in various other tauopathies, such as fronto-temporal dementia (FTD); these mutations are sufficient to induce both clinical symptoms and Tau pathology [reviewed in Schraen-Maschke et al. (2008), Umeda et al. (2013)]. The gene discussed is MAPT; the disease is tauopathy.