TARDBP and frontotemporal dementia: Consistent with its function as an RNA-binding protein, TDP-43 associates with many other RNA-binding proteins, such as hnRNP A2/B1, hnRNP A1, hnRNP C1/C2, hnRNP A3, and FUS (which is involved in splicing processes and whose mutations are responsible for 5% of FTD) (Yang et al., 1998; Buratti et al., 2005; Freibaum et al., 2010; Ling et al., 2010).