MAPT and myotonic dystrophy type 1: Surprisingly, Tau splicing remains unchanged in the brains of MBNL1 KO mice, a model that reproduces some of the muscle abnormalities, the cataracts, and the mis-splicing of some RNA transcripts, such as TNNT2 and TNNT3, observed in DM1 (Kanadia et al., 2003; Suenaga et al., 2012).