By contrast, the inclusion of the Tau exon 3-encoded sequence diminishes the fibrillar extension, consistent with a potential protective effect of exon 3, as suggested by its higher inclusion in association with the H2 haplotype, a protective haplotype with respect to tauopathy development, compared with H1 haplotype (Trabzuni et al., 2012). The gene discussed is MAPT; the disease is tauopathy.