IFNAR1 and pneumococcal infection: Evidence in support of that IL-27 mediated the inhibitory effects of IFNAR signalling on IL-17A production in γδ T cells during secondary pneumococcal infection was further provided by our demonstration that neutralization of IL-27 abrogated the inhibitory effects of IFN-β on the development of IL-17A-pruducing γδ T cells in vitro.