This might provide a molecular basis for the interesting findings reported by Wirtz et al, who described that mice deficient for the EBI3 subunit of IL-27 displayed significantly enhanced neutrophil migration, which resulted in enhanced Escherichia coli clearance and local control of infection in septic peritonitis (Wirtz et al, 2006), because IL-17 production in γδ T cells was also important for local neutrophil influx and protection againstE. This evidence concerns the gene EBI3 and infection.