IL10 and pneumococcal infection: Another immunosuppressive action of IL-27 is mediated by IL-10 production, however, several independent research groups have demonstrated that there was no significant difference between WT and IL-10-deficient mice in susceptibility to secondary pneumococcal infection (Shahangian et al, 2009; Sun & Metzger 2008), indicating that IL-27-mediated IL-10 expression is unlikely to be responsible for the regulatory effects of IL-27 on antibacterial immunity in our model.