TAMOF is characterized as a thrombotic microangiopathic process, similar to that described in thrombotic thrombocytopenic purpura (TTP), which is characterized by decreased ADAMTS13 protease activity causing accumulation of large, multimeric von Willebrand Factor (vWF) [44]. The gene discussed is ADAMTS13; the disease is thrombotic thrombocytopenic purpura.