Thanks to their ability to inhibit both MAO A and MAO B activity (Patsenka and Antkiewicz-Michaluk 2004) and to scavenge free radicals (Antkiewicz-Michaluk et al. 2006), TIQ and its close methyl derivative, 1MeTIQ may be useful not only for the therapy of neurodegenerative disease (e.g., PD) but also in the treatment of the depression as new antidepressants. This evidence concerns the gene MAOB and major depressive disorder.