Mutations in PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PINK1 (PTEN-induced putative kinase 1) have been linked to neurodegenerative disease processes affecting ALS, Parkinson's and Alzheimer's Diseases (Domanskyi et al., 2011; Kirby et al., 2011; Wilhelmus et al., 2011; Morimoto et al., 2010; Sonoda et al., 2010; Valente et al., 2004). The gene discussed is PTEN; the disease is early-onset autosomal dominant Alzheimer disease.