TARDBP and amyotrophic lateral sclerosis: In fact, the Caenorhabditis elegans FOXO3a ortholog, DAF-16 was shown to be required for lifespan extension and improved movement by reducing the toxic effects of TDP-43 (transactive response DNA binding protein 43) and SOD1 (superoxide dismutase 1) (Boccitto et al., 2012; Vaccaro et al., 2012; Zhang et al., 2011) which have both been linked to sporadic and familial forms of ALS (Sreedharan et al., 2008; Kabashi et al., 2008; Rosen et al., 1993; Jones et al., 1993).