SOD2 and amyotrophic lateral sclerosis: In addition, SOD2 has been implicated in mitochondrial dysfunction and examined for its role in models of neurodegenerative diseases including stroke, ALS, and Parkinson's, Alzheimer's, and Huntington's Diseases (Flynn and Melov, 2013; Maier and Chan, 2002; Andreassen et al., 2000).