Niu et al. [8] reported that FOXP3-expressing melanoma cells inhibited the proliferation of anti-CD3/anti-CD28-activated T-cells through FOXP3-induced expression of T cell inhibitory molecules on melanoma cells (B7-H1 and Fas ligand) and secreted immunosuppressive factors (TGF-β). The gene discussed is FOXP3; the disease is melanoma.