Table 1 shows two upregulated and four downregulated proteins in LPS-stimulated A375 melanoma cells, compared with control cells. The upregulated proteins were identified as pyrophosphatase and ubiquitin carboxyl-terminal esterase. The downregulated proteins were cargo selection protein TIP47, prohibitin, ATP synthase and TRX. Table 2 shows five upregulated and three downregulated proteins in A375 melanoma cells stimulated with LPS and then treated with rhTRX, compared with control cells. This evidence concerns the gene PLIN3 and melanoma.