Table 1 shows two upregulated and four downregulated proteins in LPS-stimulated A375 melanoma cells, compared with control cells. The upregulated proteins were identified as pyrophosphatase and ubiquitin carboxyl-terminal esterase. The downregulated proteins were cargo selection protein TIP47, prohibitin, ATP synthase and TRX. Table 2 shows five upregulated and three downregulated proteins in A375 melanoma cells stimulated with LPS and then treated with rhTRX, compared with control cells. The gene discussed is TXN; the disease is melanoma.