TNF and obesity due to melanocortin 4 receptor deficiency: MCP-1 participates in adipogenesis, and its deficiency is known to prevent high-fat-induced obesity.54 IL-6 is also involved in lipid metabolism as well as inflammatory processes.55 As depicted in the CBA results (Figure 4), rhTRX dose dependently reduced LPS-stimulated secretion of inflammatory cytokines IL-6, MCP-1, IFN-γ and TNF-α.