Furthermore, it has also been recommended for the treatment of cough in patients with COPD.8,26 In children and adults with poorly controlled asthma, theophylline significantly improved symptom scores for cough and wheeze compared with placebo,7 and it has been shown to be effective for treating angiotensin-converting enzyme inhibitor–related cough.9 The gene discussed is ACE; the disease is chronic obstructive pulmonary disease.