Intriguingly, multiple mutations of zinc finger proteins (ZNF) were detected in the metastasis samples; among these, metastasis-specific genetic mutations of ZNF257 and ZNF682 have been reported to be upregulated in metastatic cell lines (lung and bone), relative to the parental line of breast adenocarcinoma [15]. This evidence concerns the gene ZNF146 and breast adenocarcinoma.