In addition, mutations in known cancer gene suppressor TP53 were also detected in our study samples, including a nonsense mutation (E343*) in the regulator of TAT binding and a missense mutation (N131D) in the DNA-binding domain, both were previously reported by COSMIC (http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/) (Additional file 1: Table S3). This evidence concerns the gene TP53 and cancer.