In both unadjusted (Additional file1: Table S1) and adjusted (Table 3) analysis in the combined cohorts, total methylation was higher in those with CMH than in those with an absence of CMH, as was methylation prevalence of SULF2, JPH3, p16 and PCDH20 (p < 0.01, all analyses). This evidence concerns the gene SULF2 and hypertrophic cardiomyopathy 1.