Furthermore, MMR-proficient HCT116+ch3 and their 5-FU resistant counterpart cell lines are more sensitive to 5-FU and/or curcumin, indicating an important role for the involvement of DNA MMR-system in mediating chemosensitization in cancer cells - a topic that is of burgeoning clinical relevance for the management of CRC patients that frequently become refractory to conventional chemotherapy. Here, MRC1 is linked to cancer.