As transcription of TNF-a is regulated by the promoter region of TNF-a gene, many studies have shown that polymorphisms located in TNF-a promoter region [such as 238 (rs361525), 308 (rs1800629), 857 (rs1799724), and 1031 (rs1799964)] could regulate TNF-a production, thus affecting the risk of cancers [16]–[18]. This evidence concerns the gene TNF and cancer.