TNF and colorectal cancer: When stratified by ethnicity, for Western populations, a significant association between TNF-a 308 and colorectal cancer risk was observed under homozygote comparison [AA vs. GG, OR (95% CI) = 1.39 (1.01–1.91)], but not heterozygote comparison [AG vs. GG, OR (95% CI) = 1.04 (0.94–1.15)].