According to the conclusions of the Barcelona-2000 European Association for the Study of the Liver (EASL) conference, HCC could be diagnosed without biopsyin cases where AFP is greater than 400 ng/ml with a nodule larger than 2 cm, showing evidence of arterial hypervascularization in cirrhotic patients[12].Incolorectal carcinoma(CRC),preoperative carcinoembryonic antigen (CEA) level is a highly significant prognostic covariate and it is recommended by the American Society of Clinical Oncology (ASCO) that it should be tested pre-operatively to provide prognostic information [13]. This evidence concerns the gene CEACAM5 and hepatocellular carcinoma.