Proteomics-based method to identify apoptosis-related proteins in gastric cancer was previously reported by Bai Z. et al [30].Nevertheless, differential expression proteins of the present study were not identical to Bai's report suggesting ENO1, GRP78, GRP94, PPIA, PRDX1 and PTEN as potential gastric cancer biomarkers.Regarding the development of gastric cancer, it is a complicated process, and exhibits interactions between host, environment, and bacteria such as Helicobacter pylori.A single factor or protein could not be able to predict the occurrence and progression of gastric cancer. This evidence concerns the gene HSP90B1 and gastric cancer.