E2F3 and central nervous system cancer: BRD7 has been characterized as a potential nuclear transcription factor that regulates cell cycle progression through the Rb/E2F pathways [26], and has been shown to induce cell apoptosis in NPC [27].The study presented herein demonstrated that LNA-mediated miR-182 and miR-381 silencing in gliomas blocked cell cycle progression in the G0/G1 phase by regulating pRb and E2F3 and inhibited cell proliferation in vitro and growth in vivo.