Gliomas are the most common type of primary brain malignancies and are characterized by well-defined genetic alterations and frequent chromosomal aberrations that are associated with tumorigenesis[1].The chromosome region 7q31-32 is thought to contain multiple tumor-suppressor genes involved in the pathogenesis of head and neck tumors, one of which is the leucine-rich repeat C4 (LRRC4) gene [2]. Here, LRRC4 is linked to central nervous system cancer.