miR-182 and miR-381 were also determined to be involved in the pathological progression of astrocytoma by targeting LRRC4. Suppressing endogenous expression of miR-182 and miR-381, respectively, restored the activation of LRRC4 in gliomas, and inhibited glioma cell proliferation in vitro and growth of subcutaneously transplanted tumor in vivo. This evidence concerns the gene LRRC4 and central nervous system cancer.