We have confirmed that LRRC4 is a target gene of miR-381, at the same time, overexpression of LRRC4 also downregulated the expression of miR-381 in glioma cells, the interaction of miR-381 and LRRC4 is involved in glioma growth[17]; when the miRNAs were used for query, it was found that miR-381 targets both LRRC4 and BRD7, which is cloned by our laboratory [18]. This evidence concerns the gene BRD7 and central nervous system cancer.