LRRC4 and central nervous system cancer: ISH analysis of miR-182 and miR-381 and IHC analysis of BRD7 and LRRC4 showed that all 47 primary gliomas had elevated levels of miR-182, miR-381, and BRD7 (except for one case), and decreased levels of LRRC4 (except for two cases), as compared to levels detected in the 21 normal brain tissues.