miR-182 and miR-381 were also determined to be involved in the pathological progression of astrocytoma by targeting LRRC4. Suppressing endogenous expression of miR-182 and miR-381, respectively, restored the activation of LRRC4 in gliomas, and inhibited glioma cell proliferation in vitro and growth of subcutaneously transplanted tumor in vivo. Here, LRRC4 is linked to astrocytoma (excluding glioblastoma).