Furthermore, patients with AKI in ICU, Emergency Department or general hospital ward had distinct causes including ischemia, sepsis, contrast media and renal toxin, which can affect the expression of KIM-1.Yun Huang et al had revealed that urinary KIM-1 level was the highest in ischemic acute tubule necrosis patients [15]. The gene discussed is HAVCR1; the disease is acute kidney injury.