EVs were captured by cells of different origins, as suggested by the presence of CD133 in different recipient cells, including M1 (human fibroblastoid cell line), SK-HEP-1 (human hepatic endothelial cells), U2OS (human osteosarcoma cell line), and less efficiently by SH-SY5Y (human neuroblastoma cell line) and BXPC3 (human primary pancreatic adenocarcinoma cells) (Figure 7). The gene discussed is PROM1; the disease is neuroblastoma.