Hepatic Wnt5a, JNK1 p54 and JNK1 p46 protein levels of the T2DM-NASH-Cele group were all strongly reduced than those from the T2DM-NASH group (Fig. 4A and B), as was hepatic Wnt5a mRNA (Fig. 5A). Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.