Western blot analysis showed that hepatic Wnt5a, JNK1 p54 and JNK1 p46 protein levels in the T2DM-NASH group were significantly increased compared with those of the control group and control-cele group (Fig. 4A and B), as was hepatic Wnt5a mRNA (Fig. 5A). Here, MAPK8 is linked to type 2 diabetes mellitus.