IHC staining for Wnt5a and JNK1 in livers from the T2DM-NASH group were both strongly positive (Fig. 3C and G), whereas they were almost negative in the control group (Fig. 3A and E) and the control-cele group (Fig. 3B and F). This evidence concerns the gene MAPK8 and metabolic dysfunction-associated steatohepatitis.