We have previously observed Tie2 activation in synovial macrophages of patients with RA and psoriatic arthritis, a form of spondyloarthritis (SpA) [19], and in RA and other forms of arthritis, distinct macrophages with M2-like and mixed M1/M2 phenotypes are observed [20], [22], [37]. The gene discussed is TEK; the disease is Arthritis.