EN2 and autism: Six studies to date investigated whether the WNT2 gene is associated with autism, another neurodevelopmental disorder [179, 181-184], with three studies finding rare mutations in the WNT2 gene to increase significantly the susceptibility to autism [179, 182, 183], while another found a possible interaction between two SNPs, one for WNT2 and one for EN2, in influencing language development in autism [184].