This study also reported a significant association between APC mutations and schizophrenia using the transmission disequilibrium test (TDT) in Chinese trio families with schizophrenia; three SNPs at the exon region in the APC gene were found to be associated with schizophrenia, i.e., rs2229992, rs42427, and rs465899 [261]. This evidence concerns the gene APC and schizophrenia.