APC and schizophrenia: Interestingly, Apc heterozygous knockout mice display working memory deficits (a condition shared by people with schizophrenia) when they are 11-12 weeks-old, an age roughly corresponding to 16-18 years of age in humans, but not at 6-7 weeks of age, which is about 10 years for humans [129]; the parallel with age of onset of schizophrenia is impressive.