DKK1 and Alzheimer disease: In Drosophila models of neurodegeneration, Wnt dysregulation can lead to neurofibrillary pathology [117] and the overexpression of Dvl1 increases the non-amyloidogenic α-secretase cleavage of APP [118] while DKK1-neutralizing antibodies are protective against synaptic loss in mouse models of AD [119].