CAMK4 and Alzheimer disease: Recently, studies on the relationships between Wnt/ β-catenin pathway and spatial memory have described that the expression of the calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is modulated by Wnt3a and that the administration of lithium restores the levels of CaMKIV and improves the spatial memory deficits in a transgenic model of AD [77].