Interest in the role of dopamine in migraine was motivated after Peroutka et al. 1997 identified a susceptibility polymorphism at rs61689984 in the DRD2 gene with increased frequency of the C allele in migraine with aura (0.84) compared to migraine without aura (0.70) and controls (0.71) [95]. The gene discussed is DRD2; the disease is migraine disorder.