Multivariate Cox model analysis showed that RAB25 mRNA level was an independent risk factor for LRFS (HR: 3.00, 95% CI [1.46–6.17], P = 0.003), PFS (HR: 2.49, 95% CI [1.41–4.41], P = 0.002), and CSS (HR: 3.84, 95% CI [1.93–7.62], P < 0.001) in locally advanced HNSCC patients (Table 2). The gene discussed is RAB25; the disease is head and neck squamous cell carcinoma.