CRYAB and hepatocellular carcinoma: These included some important genes like DNA replication licensing protein MCM2, which is tested as biomarker for screening of cervical lesions [29]; CENPF which plays a role in chromosome segregation during mitosis and is reported to be frequently amplified in hepatocellular carcinoma [30]; PRC1 which is involved in cytokinesis [31]; and CRYAB a tumor suppressor [32].