Analyzing all the cancer biopsies for RB1 and CtIP/RBBP8 patterns revealed a strong statistically significant correlation between RB1 and CtIP/RBBP8 (Table 3): in more than 90% of those samples in which CtIP/RBBP8 was absent, RB1 was also either absent or reduced. Here, RBBP8 is linked to cancer.