As our previous work has shown that the Notch pathway is minimally active in MTC-TT cells, we wanted to examine the potential of thiocoraline to induce the expression levels of Notch isoforms (Notch1 and Notch2), which would lead to a subsequent reduction in NET markers ASCL1, CgA, calcitonin, and SYP. The gene discussed is SYP; the disease is medullary thyroid gland carcinoma.