In the prostate cancer samples, increased GLCE expression was positively associated with advanced disease (Pearson correlation coefficients GLCE/Gleason = 0.56, P < 0.05; GLCE/TNM = 0.62, P < 0.05; and GLCE/PSA = 0.88, P < 0.01), while no evident correlation was shown between GLCE expression and the clinical parameters for the prostate tumors both with normal and decreased GLCE expression (Table 1). This evidence concerns the gene KLK3 and Familial prostate cancer.