While a number of studies have demonstrated the multiple roles of this pathway in tumor progression where transfection of β-catenin siRNA into colon and breast cancer cells led to the induction of metastatic genes whereas stabilization of β-catenin by lithium chloride or treatment with glycogen synthase kinase-3b (GSK-3b) inhibitor decreased their expression 40–42. Here, GSK3B is linked to breast cancer.