EPAS1 and lung cancer: Instead, BAY 87-2243 inhibited HIF-1α and HIF-2α protein accumulation in lung cancer cell line H460 under hypoxic conditions but had no effect on HIF-1α protein levels in H460 cells induced by the hypoxia mimetics desferrioxamine or cobalt chloride, indicating that PHD activity is essential for compound effect on HIF-1α.