In CRC cells, hERG1 channels regulate pAkt, through the formation, on the plasma membrane, of a macromolecular complex between hERG1, the β1 integrin, and the p85 subunit of phosphatidyl inositol-3-kinase, which leads to the activation of Akt (O. Crociani et al., pers. This evidence concerns the gene KCNH2 and colorectal carcinoma.