In particular, K+ channels of the ether-à-go-go (EAG) family, mainly human ether-à-go-go-related gene (hERG1) 14 and EAG-1 15, were found to be overexpressed in several types of human cancers 13,16, including CRC 17–20. This evidence concerns the gene KCNH1 and colorectal carcinoma.