Our finding that the concomitant hERG1 and, probably transgene induced, mERG1 overexpression in the large intestine increases the number of AOM-induced MDF and polyps, strongly indicates that an upregulation of hERG1 accelerates the process of colorectal carcinogenesis, further stressing the role of hERG1 as a progression gene in CRC. Here, KCNH2 is linked to medical procedure.