KCNH2 and torsades de pointes: When Apcmin/+ mice were treated with the specific hERG1 blocker E4031, daily for 3 months, such long-term mERG1 current inhibition 28–32, that, in agreement with a previous paper 33, did not lead to drug-induced torsades de pointes in E4031-treated mice, produced an impairment in colonic lesion development (Fig. 1C).