Azoxymethane (AOM), a 1,2-dimethylhydrazine metabolite 9,10, triggers colonic tumorigenesis in rodents 11, which almost totally reproduces the genetic and molecular alterations underlying CRC tumor progression 12, through a multistep process involving precancerous lesions such as mucin-depleted foci (MDF), adenomas, and cancers 10. This evidence concerns the gene MUC5AC and colorectal carcinoma.