Significantly amplified genes (BTBD7, CAMSAP1L1, CHRDL2, FBXO7, GMPK2, HBEGF, IRF9, KHDRBS1, NPM3, PAIP2, PARP1, RAB1A, REC8 and TBRG4) and significantly deleted genes (CSMD1 and MYO5B) were detected in progressive leukoplakia and OSCCs, and not in non-progressive lesions. The gene discussed is CHRDL2; the disease is leukoplakia.