KDR and posterior cortical atrophy: Finally, Dyn2 directly interacts with F-actin and actin dynamics, actin-associated proteins, molecules that induce or sense membrane curvature, as well as expression of angiogenic receptors, e.g., vascular endothelial growth factor receptor 2/Kinase insert domain receptor, in endothelial cells 36,37, but future studies are required to delineate the impact of Dyn2 silencing on each of these mechanisms in progressive PCA.