ATM and lung cancer: Specifically, the concentrations of 2-butanone, 3-hydroxy-2-butanone, 2-hydroxyacetaldehye, and 4-HHE in breath are readily determined by FT-ICR-MS analysis of the respective ATM-VOC adducts, and elevated concentrations of these adducts relative to concentrations in healthy patients, or even patients with benign pulmonary nodules, indicate the presence of lung cancer.