TGFB1 and tuberculosis: TGF-β was confirmed as an attractive TB target in a second, independent study where the lungs of chronically infected mice were treated with siRNA targeting TGF-β1; this led to a modest decrease of bacterial burden in C57/BL6 mice and, to a greater degree, in IL-10 knock-out mice (Rosas-Taraco et al, 2011).