Finally, we combined the results from both steps of the study and performed a Mantel-Haenszel meta-analysis observing that the PPARG genetic variant showed suggestive evidence of association with SSc (PMH = 5.00 × 10-7; OR = 1.25; CI, 95%, 1.15 to 1.37) (Table 2, lower rows; Figure 1). This evidence concerns the gene PPARG and systemic sclerosis.