Eleven of the focal CNAs (smaller than 5 Mb and containing a tumor-related gene) were found to be recurrent, such as lesions involving the RB1, LEU2, DLEU1, DLEU7, and TP53 genes, whereas other CNAs encompassed genes (i.e., MGA, NFKB2 and FBXW7) known to play a role in CLL[5,7]. The gene discussed is RB1; the disease is B-cell chronic lymphocytic leukemia.