While ischemia-induced conditions are closely associated with TRPV1 activation [15-19], and TRPV1 is the endpoint target of a variety of sensitizing substances including protons and ATP [1,5,6], TIIP rats show no hypersensitivity to heat stimuli, i.e. thermal hyperalgesia (TH), and changes in the pharmacological activity of peripheral TRPV1 is not detected in this model [13,14]. The gene discussed is TRPV1; the disease is ischemia.