To test this, wild type p21 or p27 promoter reporter constructs (denoted p21Luc and p27Luc, respectively) were cotransfected with the Stat6 expression plasmid in PR-positive breast carcinoma T47D cells [33,34], and the cells were treated with progesterone or left untreated (Figure 1). Here, PGR is linked to breast carcinoma.