The proposed relationship between NF-kB and the proinflammatory and proapoptotic effects of IFI16 could be supported by the work of Lam et al. [72], in which they suggested that obstetric complications in the form of perinatal hypoxia may lead to inflammation and apoptosis, and may contribute to an increased risk of neurodevelopmental disorders such as autism through increased expression of transcription factors, NF-κB, inflammatory mediators, IL-6, and the apoptotic protein caspase3. The gene discussed is IL6; the disease is autism.