Both RNAi and overexpression effectively altered total cellular APE1 protein levels at 48 hours after transduction according to the Western blot shown in Figure 3A. Noteworthy, since the B cell origin of both parental MM cell lines, we found that the APE1 knockdown rendered no significant growth inhibition under untreated conditions, which agrees with previous reports[23,24]. Here, APEX1 is linked to Miyoshi myopathy.