IGFBP-2 was significantly elevated in the CSF, but not serum, of children with CNS tumors (p < 0.001), contrasting the findings of de Bont et al. who failed to show elevations in IGFBP-2 in the CSF of medulloblastoma and ependymoma patients (22). This evidence concerns the gene IGFBP2 and ependymoma.