Considering its obvious effect on the actin cytoskeleton, YpkA is believed to act as another important virulent factor, in addition to YopH, YopE, and YopT, in inhibiting phagocytosis of Y. pestis by host cells during infection (Wiley et al., 2006), as YpkA can sequester Rac and block Rac-dependent Fcγ receptor-mediated phagocytosis at the plasma membrane; however, this is not observed with RhoA and RhoA-dependent complement-mediated phagocytosis (Groves et al., 2010) as RhoA is trapped in the cytosol by endogenous RhoGDIα (Groves et al., 2010). This evidence concerns the gene AKT1 and infection.