Similar over-expression of Top1 protein have been reported in urinary bladder carcinomas (77%) (72), gastric carcinomas (68%) (73), testicular tumors (74), renal cell carcinomas (36–100%) (75), malignant melanomas (42%) (76), squamous cell carcinomas (92%) (77), and sarcomas (13%) (78). The gene discussed is TOP1; the disease is melanoma.