TOP1 and cancer: Several classes of cytotoxic agents, such as Top1 inhibitors (irinotecan, topotecan), topoisomerase II inhibitors (etoposide), anthracyclines (epirubicin, doxorubicin, mitoxantrone), taxanes (docetaxel, paclitaxel), anti-mitotics (vinorelbine, eribulin), antimetabolites (capecitabine, gemcitabine), or platinum analogs (cisplatin, carboplatin) can be used for the treatment of cancer, be it in the adjuvant, neoadjuvant, or metastatic setting.