TIMP-1 is of particular interest in the pathogenesis of liver fibrosis, as its function is to block matrix metalloproteinase activities, thus forcing the equilibrium of matrix synthesis/degradation away from degradation, ultimately resulting in stabilization of collagen fibers and other extracellular matrix compounds (Gomez et al. 1997; Arthur et al. 1998). Here, TIMP1 is linked to Hepatic fibrosis.