CASP1 and melanoma: Recently it was found that the activation of caspase-1 is mediated by the inflammasome, a protein complex composed of PRRs including AIM2 (Absent In Melanoma 2) or NLRP3 (NOD-like receptor family, pyrin domain containing 3), adaptor protein ASC (apoptosis-associated specklike protein containing a CARD) as well as pro-caspase-1 [16], [19].