In fact, based on protein-coding gene expression profiling, breast tumors can be classified at least in three major subtypes: luminal or estrogen receptor positive (ER+), basal or triple negative and human epidermal growth factor receptor 2 positive (HER2+) breast tumors [4], [5], [6], [7], which are associated with different clinical outcome. Here, ERBB2 is linked to breast neoplasm.