Thus, when we represented together BMP4 production and MSC proliferation in ALL-MSCs along the course of disease, a correlation could be established between the high production of BMP4 and the low levels of MSC proliferation at diagnosis, followed by a gradual decrease of BMP4 production during treatment (+15, +35) that correlated with increased rates of cell proliferation (Fig. 6D). The gene discussed is BMP4; the disease is acute lymphoblastic leukemia.