TNFRSF12A and systemic lupus erythematosus: Finally, it is important to note that not only is TWEAK/Fn14 signaling involved in NPSLE, but this cytokine/receptor pair has been implicated in the pathogenesis of injury in other major lupus target organs, including the kidney [for which there is evidence both in murine models (105, 106), and in human disease (107)], and in cutaneous lupus as well (108).