Nara et al. stimulated HUVEC with monoclonal antibodies targeted toward thrombomodulin, a proposed antigenic substrate of some AECAs in SLE patients (83), and found increased endothelial production of IL-6 and IL-8 mediated through the NF-κB pathway (84). The gene discussed is CXCL8; the disease is systemic lupus erythematosus.